==== Reference: Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.====

Detailed description page of THPdb

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1129 details
Primary information
ThPP IDTh1018
Therapeutic Peptide/Protein NameSecretin
SequenceHSDGTFTSELSRLRDSARLQRLLQGLV view full sequnce in fasta
Functional ClassificationIV
Molecular Weight3056.4
Chemical FormulaC130H219N43O42
Isoelectric Point9.45
Hydrophobicity-0.463
Melting Point (℃)N.A.
Half LifeN.A.
DescriptionThis drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secretin is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.
Indication/DiseaseFor diagnosis of pancreatic exocrine dysfunction and gastrinoma
PharmacodynamicsSecretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.
Mechanism of ActionSecretin binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesDiagnostic Agents
Patents NumberN.A.
Date of IssueN.A.
Date of ExpiryN.A.
Drug InteractionClidinium. Anticholinergic agents such as secretin may diminish the stimulatory effect of secretin. Avoid using drugs with substantial anticholinergic effects in patients receiving secretin whenever possible. If such agents must be used in combina
TargetSecretin receptor
Information of corresponding available drug in the market
Brand NameSecreFlo
CompanyRepligen Corp
Brand DiscriptionSecreFlo is a pure sterile, nonpyrogenic, lyophilized white cake powder acetate salt of secretin, a peptide hormone. Secretin has an amino acid sequence identical to the naturally occurring porcine secretin consisting of 27 amino acids.
Prescribed forTesting for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction.
Chemical NameH-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser- Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2
FormulationN.A.
Physcial AppearnceLyophilized white powder
Route of AdministrationIntravenous infusion
Recommended DosageN.A.
ContraindicationAllergy
Side EffectsAbdominal discomfort, Nausea, Mild bradycardia (reduced heart rate), Decreased blood pressure and Diaphoresis (profuse perspiration)
Useful Linkhttp://www.medilexicon.com/drugs/secreflo.php
PubMed ID15780490, 20641871, 25619391
3-D StructureTh1018 (View) or (Download)