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1064 details
Primary information
ThPP IDTh1011
Therapeutic Peptide/Protein NameDarbepoetin alfa
SequenceAPPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYA view full sequnce in fasta
Functional ClassificationIb
Molecular Weight18396.1
Chemical FormulaC815H1317N233O241S5
Isoelectric Point8.75
Hydrophobicity-0.188
Melting Point (℃)53
Half LifeN.A.
DescriptionHuman erythropoietin with 2 amino acid substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW 37kD) produced in CHO cells by recombinant DNA technology.
Indication/DiseaseFor treating anemia (from renal transplants or certain HIV treatment).
PharmacodynamicsDarbepoetin alfa is used in treating anemia. It is involved in the regulation of erythrocyte differentiation and maintenance of a physiological level of circulating erythrocyte mass.
Mechanism of ActionDarbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin, it interacts with progenitor stem cells to increase red cell production. Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization.
ToxicityN.A.
MetabolismN.A.
AbsorptionN.A.
Volume of DistributionN.A.
ClearanceN.A.
CategoriesAnti-anemic Agents
Patents NumberCA2165694
Date of Issue18/03/03
Date of Expiry15/10/10
Drug InteractionN.A.
TargetErythropoietin receptor
Information of corresponding available drug in the market
Brand NameAranesp
CompanyAmgen Inc
Brand DiscriptionAranesp is an erythropoiesis-stimulating protein that is produced in Chinese hamster ovary cells by recombinant DNA technology. Aranesp is a 165-amino acid protein (37,000 daltons) that differs from recombinant human erythropoietin in containing 5 N-linke
Prescribed forUsed to treat anemia.
Chemical NameN.A.
FormulationEach 1 mL contains polysorbate 80 (0.05 mg), sodium chloride (8.18 mg), sodium phosphate dibasic anhydrous (0.66 mg), and sodium phosphate monobasic monohydrate (2.12 mg) in Water for Injection, USP (pH 6.2 ± 0.2).
Physcial AppearnceSterile, colorless, preservative-free solution containing polysorbate
Route of AdministrationIntravenous or Subcutaneous administration
Recommended DosageN.A.
ContraindicationAllergic
Side EffectsFever, chills, body aches, flu symptoms; feeling like you might pass out; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; seizure (black-out or convulsions); or dangerously high blood pressure.
Useful Linkhttp://www.aranesp.com/
PubMed ID23847411, 23338536, 23325012, 23243269, 22803621, 22192713, 20140276, 18837016, 16179960
3-D StructureTh1011 (View) or (Download)