Welcome to Help Page of RareLSD

This page provides help to the users of RareLSD database on how to use various modules that are integrated in RareLSD. For each module which is implemented in RareLSD, here we provide the figures and description on how to use that module.

Search Module

Keyword Search
This module displays the simple search page of RareLSD. Clicking on the required field will allow the user to browse the specific information in the database.

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Advance Search
This page provides the advanced search facility in RareLSD. User can browse the page by selecting two or more than two fileds.

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Search Module

Peptide Search
This module is for searching Enzyme sequences in RareLSD containing a part of query sequence.

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Browse page

Browse by Enzyme Bioassay

This module displays the bioassays curated for the enzyme in PubChem in RareLSD.

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Browse by Category of Lysosomal Disorder
This page provides us a glimpse into various categories of disorders that are caused by enzymes in RareLSD.



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Browse by Family
This page provides the distribution of enzymes categorised on teh basis of the family of proteins tehy belong to evolutionarily in RareLSD.

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Browse by Inheritance Pattern
This page provides the distribution of disorders on the basis of their inheritance pattern in RareLSD.

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Browse by Organ Affected
This page provides the distribution of disorders on the basis of diffrent organs affected in RareLSD.

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Browse by Age of Onset
This page provides the distribution of disorders on the basis of enzyme location within the lysosome and extra lysosomal space in RareLSD.

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Secondary Structure
This page provides the percentage secondary content information in all enzymes curated in RareLSD .

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BLAST
This is the BLAST-Search page which assists users in performing BLAST search against the peptides in RareLSD Database

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Smith-Waterman
This page allows users to perform similarity search against peptides present in RareLSD using Smith-Waterman algorithm. User can submit their peptide; server will returns the list of peptides similar to the query peptide.

Frequently Asked Questions (FAQs)

Q1. What is RareLSD? Ans. RareLSD is an comprehensive information sysytem about all enyzmes present in the human lysosome. Q2. Why RareLSD? Ans. Lysosomal enzymes play a major role in maintaining natural haemostasis within the cellular compartments. Deficiency or malfunctioning of any enzyme leads to accumulation of toxic metabolites and thus, various storage defects. One major application of this database is that all the necessary information about these enzymes can be present in this portal which could be ustilised extensively to serach about the disorders caused due to such enzyme defects. . Q3. How to search into RareLSD? Ans. User can search RareLSD using various modules such as Search, Browse etc. In addition for sequence similarity search, user can explore various analysis tools that are integrated in RareLSD.