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Details of RareLSD ID 1057
RareLSD_Id1057
ENZYMEProXaa carboxypeptidase
GENEPRCP
E.C.NUMBER3.4.16.2
FAMILYpeptidase S28
CYTOGENETICS11q14.1
DISEASESarcoidosis
SNPrs6028631,rs1834182971,rs1875885671,rs1919127781,rs25102891,rs1831055891,rs5978381,rs1166572651,rs1867204121,rs72721
DEPOSITpoorly degradable antigens of either infectious or environmental origin
REF6366093, 230518
TEMP (in Celsius)37
pI9.9
pH4.5 - 5.5
Catalytic NucleophileSer179
Catalytic Acid/Base
Asp430,His455
SubstrateAlaPro+4nitroanilide + H2O
ProductAlaPro + 4-nitroaniline
Structure(PDB/Phyre2_ID)3N2Z
kM1.5
DRUGAviptadil,LPyrLGluLGlnLLeuLGluLArgLAlaLLeuLAsnLSerLSer,Nitric oxide
SEQ LENGTH496
AA SEQMGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
MODIFICATIONN-linked Glycosylation:Thr39,Asn47,Asn101,Asn317,Asn336,Asn345,Asn415,Ubiquitination:Lys77
INHIBITORNEM,Angiotensin III,benzyloxycarbonylProProaldehyde dimethyl acetate,benzyloxycarbonylProprolil,2-[4,[(4-fluorophenyl)1-methyl1-Hpyrazol5yl],(2-phenylethyl)piperidin4yl]pyridine,angiotensin I
ACTIVE SITE RESIDUESer179,Asp430,His455
DISULPHIDE BRIDGES*215-372,*233-310,*264-343,*364-394
PSEUDOGENESPGOHUM00000240230
MISCELLANEOUSThe Ser, Asp, His catalytic triad has been determined from the crystal structure
PARALOGSPRSS16,DPP7
MECHANISMCleavage of a Pro|Xaa bond to release a C-terminal amino acid
INHERITANCE PATTERNNot inherited
ORGAN AFFECTEDLungs,Eye,Skin,HEart
ENZYME LOCATIONOD
UniProt IDP42785