| RareLSD_Id | 1057 |
| ENZYME | ProXaa carboxypeptidase |
| GENE | PRCP |
| E.C.NUMBER | 3.4.16.2 |
| FAMILY | peptidase S28 |
| CYTOGENETICS | 11q14.1 |
| DISEASE | Sarcoidosis |
| SNP | rs6028631,rs1834182971,rs1875885671,rs1919127781,rs25102891,rs1831055891,rs5978381,rs1166572651,rs1867204121,rs72721 |
| DEPOSIT | poorly degradable antigens of either infectious or environmental origin |
| REF | 6366093, 230518 |
| TEMP (in Celsius) | 37 |
| pI | 9.9 |
| pH | 4.5 - 5.5 |
| Catalytic Nucleophile | Ser179 |
Catalytic Acid/Base
| Asp430,His455 |
| Substrate | AlaPro+4nitroanilide + H2O |
| Product | AlaPro + 4-nitroaniline |
| Structure(PDB/Phyre2_ID) | 3N2Z |
| kM | 1.5 |
| DRUG | Aviptadil,LPyrLGluLGlnLLeuLGluLArgLAlaLLeuLAsnLSerLSer,Nitric oxide |
| SEQ LENGTH | 496 |
| AA SEQ | MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ |
| MODIFICATION | N-linked Glycosylation:Thr39,Asn47,Asn101,Asn317,Asn336,Asn345,Asn415,Ubiquitination:Lys77 |
| INHIBITOR | NEM,Angiotensin III,benzyloxycarbonylProProaldehyde dimethyl acetate,benzyloxycarbonylProprolil,2-[4,[(4-fluorophenyl)1-methyl1-Hpyrazol5yl],(2-phenylethyl)piperidin4yl]pyridine,angiotensin I |
| ACTIVE SITE RESIDUE | Ser179,Asp430,His455 |
| DISULPHIDE BRIDGES | *215-372,*233-310,*264-343,*364-394 |
| PSEUDOGENES | PGOHUM00000240230 |
| MISCELLANEOUS | The Ser, Asp, His catalytic triad has been determined from the crystal structure |
| PARALOGS | PRSS16,DPP7 |
| MECHANISM | Cleavage of a Pro|Xaa bond to release a C-terminal amino acid |
| INHERITANCE PATTERN | Not inherited |
| ORGAN AFFECTED | Lungs,Eye,Skin,HEart |
| ENZYME LOCATION | OD |
| UniProt ID | P42785 |
