| RareLSD_Id | 1056 |
| ENZYME | Phospholipase A2, Group XV |
| GENE | PLA2G15 |
| E.C.NUMBER | 2.3.1- |
| FAMILY | lipase |
| CYTOGENETICS | 16q22.1 |
| DISEASE | NA |
| SNP | rs1000104782,rs1000196353,rs1000289923,rs1000556318,rs1000662083 |
| DEPOSIT | lysophosphatidylcholine |
| REF | 11790796, 25727495 |
| TEMP (in Celsius) | 0 |
| pI | NA |
| pH | NA |
| Catalytic Nucleophile | NA |
Catalytic Acid/Base
| NA |
| Substrate | NA |
| Product | NA |
| Structure(PDB/Phyre2_ID) | 4X90 |
| kM | NA |
| DRUG | NA |
| SEQ LENGTH | 412 |
| AA SEQ | MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP |
| MODIFICATION | N-linked Glycosylation: :Asn99,Asn273,Asn289,Asn398 |
| INHIBITOR | amiodarone |
| ACTIVE SITE RESIDUE | Ser198,Asp360,His392 |
| DISULPHIDE BRIDGES | *65-89 |
| PSEUDOGENES | NA |
| MISCELLANEOUS | NA |
| PARALOGS | LCAT |
| MECHANISM | Catalyzes the formation of 1O-acylN-acetylsphingosine and the concomitant release of a lysophospholipid |
| INHERITANCE PATTERN | NA |
| ORGAN AFFECTED | NA |
| ENZYME LOCATION | NA |
| UniProt ID | Q8NCC3 |
