Welcome to Entry Card of Lysosomal Enzymes
Details of RareLSD ID 1050 |
| RareLSD_Id | 1050 |
| ENZYME | Myeloperoxidase |
| GENE | MPO |
| E.C.NUMBER | 1.11.2.2 |
| FAMILY | Peroxidase |
| CYTOGENETICS | 17q22 |
| DISEASE | Myeloperoxidase deficiency |
| SNP | rs119468010,rs119469012,rs119469013,rs119469014,rs28730837 . |
| DEPOSIT | NA |
| REF | 19544176, 19651119, 17479404 |
| TEMP (in Celsius) | 37 |
| pI | NA |
| pH | 4.7 - 6 |
| Catalytic Nucleophile | NA |
| Catalytic Acid/Base | His261 |
| Substrate | donor + H2O2 |
| Product | oxidized donor + H2O |
| Structure(PDB/Phyre2_ID) | 5FIW |
| kM | NA |
| DRUG | Carnosine,Melatonin,2-Phenylacetamide,4-Coumaryl alcohol,Calcium,Cyanosulfurous acid anion,Formaldehyde,Heme,Hydrogen peroxide,Hypothiocyanite |
| SEQ LENGTH | 745 |
| AA SEQ | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS |
| MODIFICATION | N-linked Glycosylation:Asn139,Asn316,Asn323,Asn391,Asn483,Asn729 |
| INHIBITOR | 4'amino4fluorochalcone,5thio2nitrobenzoic acid,Aminotriazole dityrosine,kaempferol7Orhamnoside,serotonin,Sulfide,Q3GA |
| ACTIVE SITE RESIDUE | His261 |
| DISULPHIDE BRIDGES | *167-180,*281-291,*285-309,*387-398,*606-663,*704-730 |
| PSEUDOGENES | NA |
| MISCELLANEOUS | NA |
| PARALOGS | LPO,TPO,EPX,PXDNL,PXDN |
| MECHANISM | Cl + H2O2 + H+ = HClO + H2O |
| INHERITANCE PATTERN | Autosomal recessive |
| ORGAN AFFECTED | Nervous System,Skin |
| ENZYME LOCATION | OD |
| UniProt ID | P05164 |