Welcome to Entry Card of Lysosomal Enzymes
Details of RareLSD ID 1036 |
| RareLSD_Id | 1036 |
| ENZYME | Deoxyribonuclease 2 alpha |
| GENE | DNASE2 |
| E.C.NUMBER | 3.1.22.1 |
| FAMILY | Dse II f |
| CYTOGENETICS | 19p13.13 |
| DISEASE | calcific tendinitis |
| SNP | rs1000431261,rs1001303266,rs1001651198,rs1001779175,rs1001787344 |
| DEPOSIT | NA |
| REF | 18812394, 15057824, 12558498 |
| TEMP (in Celsius) | 0 |
| pI | NA |
| pH | 4.5 -5 |
| Catalytic Nucleophile | NA |
| Catalytic Acid/Base | NA |
| Substrate | D + H2O |
| Product | 3' phosphooligonucleotides |
| Structure(PDB/Phyre2_ID) | c5i3eB |
| kM | NA |
| DRUG | NA |
| SEQ LENGTH | 360 |
| AA SEQ | MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGGWRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI |
| MODIFICATION | N-linked Glycosylation:Asn86,Asn212,Asn266,Asn290 |
| INHIBITOR | Ca2+,Co2+,Cu2+,Fe3+,Mg2+,Mn2+,Cl,tunicamycin,Zn2 |
| ACTIVE SITE RESIDUE | His295 |
| DISULPHIDE BRIDGES | *19-159,*267-347,*308-327 |
| PSEUDOGENES | NA |
| MISCELLANEOUS | NA |
| PARALOGS | DNASE2B |
| MECHANISM | Endonucleolytic cleavage to nucleoside 3'phosphates and 3'phosphooligonucleotide endproducts. |
| INHERITANCE PATTERN | NA |
| ORGAN AFFECTED | Boness |
| ENZYME LOCATION | OD |
| UniProt ID | O00115 |