Details of RareLSD ID 1031 |
RareLSD_Id | 1031 |
ENZYME | Cathepsin O |
GENE | CTSO |
E.C.NUMBER | 3.4.22.42 |
FAMILY | Papain cysteine protease (C1) |
CYTOGENETICS | 4q31q32 |
DISEASE | Breast Neoplasms |
SNP | rs10000523,rs1000091125,rs1000174042,rs10002427,rs1000247612 |
DEPOSIT | NA |
REF | 9790772 , 28514442 , 7929457 |
TEMP (in Celsius) | 0 |
pI | NA |
pH | NA |
Catalytic Nucleophile | Cys25 |
Catalytic Acid/Base | H2O |
Substrate | Fibrinogen + H2O |
Product | NA |
Structure(PDB/Phyre2_ID) | d7pcka |
kM | NA |
DRUG | NA |
SEQ LENGTH | 321 |
AA SEQ | MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV |
MODIFICATION | N-linked Glycosylation:Asn62,Asn105 |
INHIBITOR | E64 |
ACTIVE SITE RESIDUE | Gln126,Cys132,His269,Asn289 |
DISULPHIDE BRIDGES | *129-170,*163-204,*262-310 |
PSEUDOGENES | NA |
MISCELLANEOUS | NA |
PARALOGS | CTSF,CTSL,CTSW,CTSV,CTSK,CTSS,CTSH,CTSC,CTSZ |
MECHANISM | recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including ZPheArgNHMec and ZArgArgNHMec |
INHERITANCE PATTERN | Autosomal Dominant |
ORGAN AFFECTED | Skin |
ENZYME LOCATION | OD |
UniProt ID | P43234 |