| RareLSD_Id | 1010 |
| ENZYME | Acid phosphatase |
| GENE | ACP2 |
| E.C.NUMBER | 3.1.3.2 |
| FAMILY | Histidine acid phosphatase |
| CYTOGENETICS | 11-p11.2 |
| DISEASE | ACID PHOSPHATASE DEFICIENCY |
| SNP | rs1050244,rs4647760, rs4647761,rs554676341,rs1000214685 |
| DEPOSIT | NA |
| REF | 4139985 , 17357082 ,11801736 |
| TEMP (in Celsius) | 37 |
| pI | NA |
| pH | 4 |
| Catalytic Nucleophile | His108 |
Catalytic Acid/Base
| Asp/Glu |
| Substrate | lysophosphatidic acid + H2O |
| Product | monoglyceride + phosphate |
| Structure(PDB/Phyre2_ID) | d1nd6a |
| kM | 2.9 |
| DRUG | 1-Butanol,1-Hexanol,1-Pentanol,Ethanol,Isobutanol,Isopropyl alcohol,Phosphate,Propyl alcohol |
| SEQ LENGTH | 423 |
| AA SEQ | MAGKRSGWSRAALLQLLLGVNLVVMPPTRARSLRFVTLLYRHGDRSPVKTYPKDPYQEEEWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNGMQRFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNESSRNAQFLDMVANETGLTDLTLETVWNVYDTLFCEQTHGLRLPPWASPQTMQRLSRLKDFSFRFLFGIYQQAEKARLQGGVLLAQIRKNLTLMATTSQLPKLLVYSAHDTTLVALQMALDVYNGEQAPYASCHIFELYQEDSGNFSVEMYFRNESDKAPWPLSLPGCPHRCPLQDFLRLTEPVVPKDWQQECQLASGPADTEVIVALAVCGSILFLLIVLLLTVLFRMQAQPPGYRHVADGEDHA |
| MODIFICATION | N-linked Glycosylation:Asn92,,Asn133,Asn167,Asn177,Asn191,Asn267,Asn322,Asn33 |
| INHIBITOR | 4'O(2fluoromalonyl)L-tyrosinecontaining peptides,Ca2+,La3+,plasmin,salicylate,phosphoL-tyrosine peptide analogues |
| ACTIVE SITE RESIDUE | His42,Asp287 |
| DISULPHIDE BRIDGES | *159-370,*212-310,*345-349 |
| PSEUDOGENES | NA |
| MISCELLANEOUS | NA |
| PARALOGS | ACPP,ACP6,ACPT2 |
| MECHANISM | A phosphate monoester + H2O = an alcohol + phosphate |
| INHERITANCE PATTERN | Autosomal recessive |
| ORGAN AFFECTED | Nervous System |
| ENZYME LOCATION | NA |
| UniProt ID | P11117 |
