Details of RareLED ID Assay_1031 |
Primary information | |
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GENE | HEXB |
NUMBER OF ASSAY | 11 |
ASSAY IDs | 331672 1227114 1227100 748368 1314807 1227112 1227102 1227101 1227099 1227098 748372 |
Assay Name | 1. Inhibition of human beta hexosaminidase,2. Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometry,3. Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry,4. Competitive inhibition of human beta-N-acetyl-D-hexosaminidase-B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate assessed as release of 4-Methylumbelliferyl fluorophore measured for 7 mins,5. Inhibition of beta-hexosaminidase alpha/beta in human skin fibroblast lysate using 4-MU-(2-acetamido-2-deoxy)-beta-D-glucopyranoside as substrate assessed as 4-MU liberation by fluorescence assay,6. Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry,7. Inhibition of human placental HexA using pNPGlcNAc substrate,8. Inhibition of beta-N-acetylhexosaminidase (unknown origin),9. Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry,10. Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometry,11. Inhibition of human beta-N-acetyl-D-hexosaminidase-A/B using 4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide as substrate incubated for 10 mins prior to substrate addition by spectrofluorometric analysis |
ACTIVITY | Substance BioActivity: 2 Tested Substance BioActivity: 2 Active, 2 Tested Substance BioActivity: 2 Active, 2 Tested Substance BioActivity: 2 Active, 1 Activity <= 1 µM, 2 Tested Substance BioActivity: 2 Tested Substance BioActivity: 2 Active, 2 Tested Substance BioActivity: 9 Active, 17 Tested Substance BioActivity: 1 Active, 1 Tested Substance BioActivity: 2 Active, 2 Tested Substance BioActivity: 2 Active, 2 Tested Substance BioActivity: 19 Active, 3 Activity <= 1 µM, 31 Tested |