Detailed description page of Selected OV_ID


OV_824 details
Primary information
OV_IDOV_824
Virus Name Adenovirus
StrainSG611-VSTM1
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeA VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with DNR 120 ng/ml
Immune gene induction in virus genomeNo
Source of cell lineGibco, Thermo Fisher Scientific, Waltham, MA, USA
Origin of cell lineHuman acute lymphoblastic leukemic cell line
Cell lineSUP-B15
Concentration of cell line1
In-vitro toxicitySlight toxicity to L-02 and BJ cell line
AssayCell counting kit-8 (CCK-8) assay
In-vitro virus concentration80 MOI
In-vitro result38% cancer cell viability at 72 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionEnhanced apoptosis activation is observed
Immunogenic effectNA
Clinical trialNA
PMID27472927