Detailed description page of Selected OV_ID


OV_618 details
Primary information
OV_IDOV_618
Virus Name Adenovirus
StrainCRAd-CCL21-IL15
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeInsertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeIL-15
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice were injected intradermally 4 × 10⁶ Caco-2 cells
In-vivo virus concentration4 × 10⁸ IFU
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 550 cubic millimeter compared to control 3100 cubic millimeter after 40 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27380620