Detailed description page of Selected OV_ID


OV_564 details
Primary information
OV_IDOV_564
Virus Name Adenovirus
StrainOBP-301 (telomelysin)
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeViral mutant with human telomerase reverse transcriptase (hTERT) promotor for selective replication in cancer cells
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with cisplatin (CDDP, 10.0 μg/ml ) and doxorubicin (DOX, 2.5 μg/ml )
Immune gene induction in virus genomeNo
Source of cell lineDr. Satoru Kyo (Shimane University, Izumo, Japan)
Origin of cell lineHuman osteosarcoma cell line
Cell lineHOS
Concentration of cell line1
In-vitro toxicityNA
AssayXTT assay
In-vitro virus concentration100 MOI
In-vitro result10% cancer cell viability (calculated as relative to mock-infected group), synergistic effect with drugs
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27356624