Detailed description page of Selected OV_ID


OV_5455 details
Primary information
OV_IDOV_5455
Virus Name Measles virus
StrainrMV-SLAMblind
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeR533A substitution was introduced into pMV-HL(7+) and then transfected to vero cell line to produce virus particle
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice xenograft for KLM
In-vivo virus concentration1 × 10⁶ TCID50
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to below 600 cubic mm after 90 days compared to control 2500 cubic mm
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27561180