Detailed description page of Selected OV_ID


OV_5384 details
Primary information
OV_IDOV_5384
Virus Name Maraba virus
StrainMG1
Virus typeRNA
Virus familyRhabdoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with 2mg/kg micromolar palcitaxel for 48 hours
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c mice isograft for 2 × 10⁵ 4T1 cells
In-vivo virus concentrationReduction in tumor volume to 200 cubic mm compared to control 800 cubic mm after 25 days and increase in survival time to 60 days compared to 40 days control
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis
Immunogenic effectLevel of IFN beta production does not effected by combination
Clinical trialIn clinical trial for various cancer cell line
PMID27503504