Detailed description page of Selected OV_ID


OV_5338 details
Primary information
OV_IDOV_5338
Virus Name Newcastle disease virus
StrainNDV/Anh-TRAIL
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeVirus insertion for TRAIL gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismKumming mice implanted for 5 × 10⁵ H22 cells
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 10 cubic mm compared to control 3500 cubic mm after 14 days
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis as measured by TUNEL assay
Immunogenic effectCaspase 3 pathway are activated
Clinical trialNA
PMID28246027