| Primary information |
|---|
| OV_ID | OV_5275 |
| Virus Name | Herpes simplex virus |
| Strain | M002 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Deletion mutant for both copies of gamma 34.5 gene and expressing murine IL-12 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing murine IL-12 |
| Source of cell line | NA |
| Origin of cell line | Murine ovarian adenocarcinoma cell line |
| Cell line | Ig10 |
| Concentration of cell line | 4000 |
| In-vitro toxicity | NA |
| Assay | Alamar blue assay |
| In-vitro virus concentration | 33 PFU |
| In-vitro result | 1% cell viable |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | Tumor specific T cell response induced |
| Clinical trial | NA |
| PMID | 27784340 |