Detailed description page of Selected OV_ID


OV_5183 details
Primary information
OV_IDOV_5183
Virus Name Vesicular stomatitis virus
StrainVSV-MqdeltaG
Virus typeRNA
Virus familyRhabdoviridae
Modification in virus genomeAttenuated strain with 4 mutation in M protein and lacking G protein
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with Ruxolinitib 1 micromolar per litre
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice xenograft for A2780 (5 × 10⁶cells)
In-vivo virus concentration2 × 10⁵ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 0.1 cubic cm compared to control 0.7 cubic cm and increase in survival time to beyond 100 days compared to drug and alone
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27738655