Detailed description page of Selected OV_ID


OV_4946 details
Primary information
OV_IDOV_4946
Virus Name Newcastle disease virus
StrainNDV/Anh-IL2
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeInsertion of IL-2 gene between HN and L gene of pAnh-wt
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeExpressing Il-2 gene
Source of cell lineHarbin phamaceutical group bioengineering
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude mice xenograft for H22 cell line (10⁵ cells)
In-vivo virus concentration1× 10⁷ pfu every other day for four times
In-vivo toxicityNA
In-vivo resultAverage volume in control mice was 3401.25 cubic mm and decreased to 420.67 cubuc mm in treated mice, while 3 out of 6 complete regressed tumor volume
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectActivate T cells
Clinical trialNA
PMID27174862