Detailed description page of Selected OV_ID


OV_474 details
Primary information
OV_IDOV_474
Virus Name Adenovirus
StrainCRAd-IL24 (Ad5/3Δ24cmvIL24)
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeViral mutanat with IL-24 gene incorporated in place of the deleted E3B region (ΔE3B) under transcriptional control of the human CMV promoter (CMVp).
Virus aloneNo
Virus in combination iwth drug/radiationViral starin in combination with ING4
Immune gene induction in virus genomeIL-24 gene incorporated in place of the deleted E3B region
Source of cell lineATCC
Origin of cell lineHuman ovary cancer cell line
Cell lineSKOV3ip.1 OvCa
Concentration of cell line3
In-vitro toxicityToxic to normal ovarian surface epithelial IOSE-120 and IOSE-523 cells
AssayMTS-based Cell Proliferation Assay (Promega)
In-vitro virus concentration0.4 MOI
In-vitro result30% cancer cell viability (percentages are calculated with respect to mock-infected cell monolayers)
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27349517