Detailed description page of Selected OV_ID


OV_461 details
Primary information
OV_IDOV_461
Virus Name Adenovirus
StrainCRAd-ING4 (Ad5/3Δ24cmvING4)
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeViral mutanat with CMVp-driven Inhibitor of Growth 4 (ING4) gene
Virus aloneNo
Virus in combination iwth drug/radiationViral starin in combination with CRAd (a deletion adenovirus mutant of 24 nucleotides (Δ24) in the E1A gene)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman ovary cancer cell line
Cell lineSKOV3luc OvCa
Concentration of cell line3
In-vitro toxicityToxic to normal ovarian surface epithelial IOSE-120 and IOSE-523 cells
AssayMTS-based Cell Proliferation Assay (Promega)
In-vitro virus concentration100 MOI
In-vitro result14% cancer cell viability (percentages are calculated with respect to mock-infected cell monolayers)
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27349517