Detailed description page of Selected OV_ID


OV_4606 details
Primary information
OV_IDOV_4606
Virus Name Adenovirus
StrainCD55-TRAIL-IETD-MnSOD
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage site
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c mice xenograft for A549 cell (5 × 10⁶)
In-vivo virus concentration5 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultTumor volume reduced to below 100 cubic mm comapred to control 700 cubic mm after 40 days
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis
Immunogenic effectNA
Clinical trialNA
PMID27080225