Detailed description page of Selected OV_ID


OV_4538 details
Primary information
OV_IDOV_4538
Virus Name Adenovirus
StrainAd5/3-D24-GMCSF
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAd5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with cyclophospahamide (20mg/kg), intraperionoeal
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale nude NMRI mice xenograft for MDA-MB-436 (5 × 10⁶)
In-vivo virus concentration7 × 10⁹ pfu on day 1,4,8,15,29 and 43
In-vivo toxicityNA
In-vivo resultTumor volume reduced to 200 cubic mm after 61 days compared to contro 2200 cubic mm
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectVirus induced tumor specific T-cell response
Clinical trialNA
PMID27057453