Detailed description page of Selected OV_ID


OV_4530 details
Primary information
OV_IDOV_4530
Virus Name Adenovirus
StrainAd5/3-D24-GMCSF
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAd5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with Cyclophosphamide (0.05mg/ml)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman breast cancer triple negative cell line
Cell lineMDA-MB-436
Concentration of cell line1000
In-vitro toxicityNA
AssayMTS assay
In-vitro virus concentration10 VP/cell
In-vitro result62% cancer cell survival after 5 days
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectVirus induced tumor specific T-cell response
Clinical trialNA
PMID27057453