Detailed description page of Selected OV_ID


OV_447 details
Primary information
OV_IDOV_447
Virus Name Adenovirus
StrainCRAd-ING4 (Ad5/3Δ24cmvING4)
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeViral mutanat with CMVp-driven Inhibitor of Growth 4 (ING4) gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman ovary cancer cell line
Cell lineSKOV3luc OvCa
Concentration of cell line3
In-vitro toxicityToxic to normal ovarian surface epithelial IOSE-120 and IOSE-523 cells
AssayMTS-based Cell Proliferation Assay (Promega)
In-vitro virus concentration33 MOI
In-vitro result18% cancer cell viability (percentages are calculated with respect to mock-infected cell monolayers)
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27349517