| Primary information |
|---|
| OV_ID | OV_4397 |
| Virus Name | Vesicular stomatitis virus |
| Strain | Mutant |
| Virus type | RNA |
| Virus family | Rhabdoviridae |
| Modification in virus genome | Virus expressing N-Ras, cytC and TYRP-1 gene |
| Virus alone | No |
| Virus in combination iwth drug/radiation | VSV-N-Ras+VSV-cytC+ VSV-TYRP-1 |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C57BL/6 mice xenograft for GL261 cell line |
| In-vivo virus concentration | 5 × 10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | All mice survived upto day 10 fter that all was dead |
| Mode of delivery | Intravenous |
| Pathway induction | NA |
| Immunogenic effect | AntiPD-1 antibody enhances the IL-17 and IFN-gamma production |
| Clinical trial | NA |
| PMID | 26409567 |