| Primary information |
|---|
| OV_ID | OV_4395 |
| Virus Name | Vesicular stomatitis virus |
| Strain | Mutant |
| Virus type | RNA |
| Virus family | Rhabdoviridae |
| Modification in virus genome | Virus expressing HIF2alpha, Sox10 and c-Myc gene |
| Virus alone | No |
| Virus in combination iwth drug/radiation | VSV-HIF2alpha+ VSV-sox10+ VSV-cMYC |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C57BL/6 mice xenograft for GL261 cell line |
| In-vivo virus concentration | 5 × 10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | 60% mice survived on day 30, 20% mice survived on day 45 and last mice survived on day 60 |
| Mode of delivery | Intravenous |
| Pathway induction | NA |
| Immunogenic effect | AntiPD-1 antibody enhances the IL-17 and IFN-gamma production |
| Clinical trial | NA |
| PMID | 26409567 |