Detailed description page of Selected OV_ID


OV_4395 details
Primary information
OV_IDOV_4395
Virus Name Vesicular stomatitis virus
StrainMutant
Virus typeRNA
Virus familyRhabdoviridae
Modification in virus genomeVirus expressing HIF2alpha, Sox10 and c-Myc gene
Virus aloneNo
Virus in combination iwth drug/radiationVSV-HIF2alpha+ VSV-sox10+ VSV-cMYC
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC57BL/6 mice xenograft for GL261 cell line
In-vivo virus concentration5 × 10⁶ pfu
In-vivo toxicityNA
In-vivo result60% mice survived on day 30, 20% mice survived on day 45 and last mice survived on day 60
Mode of deliveryIntravenous
Pathway inductionNA
Immunogenic effectAntiPD-1 antibody enhances the IL-17 and IFN-gamma production
Clinical trialNA
PMID26409567