Detailed description page of Selected OV_ID


OV_4368 details
Primary information
OV_IDOV_4368
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with 8-CPT-cAMP (1 mmol/l)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHuman liver cancer explant
In-vivo virus concentration5 × 10⁷ pfu
In-vivo toxicitySlightly toxic to cancer cell
In-vivo result47% cancer cell growth inhibition
Mode of deliveryNA
Pathway inductionActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis
Immunogenic effectNA
Clinical trialNA
PMID26373347