Detailed description page of Selected OV_ID


OV_4364 details
Primary information
OV_IDOV_4364
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with 8-CPT-cAMP (20mg/kg/day)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice subcutaneous xenograft for HCT-116 (5 × 10⁶)
In-vivo virus concentration3 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to below 0.4 cubic centimeter after 22 days compared to control 1.2 cubic centimeter
Mode of deliveryIntravenous
Pathway inductionActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis
Immunogenic effectNA
Clinical trialNA
PMID26373347