| Primary information |
|---|
| OV_ID | OV_4290 |
| Virus Name | Alphavirus |
| Strain | M1 |
| Virus type | RNA |
| Virus family | Togaviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human glioblastoma |
| Cell line | U-138 MG |
| Concentration of cell line | 4000 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 10 pfu |
| In-vitro result | 40.1 % cell viability after 72 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26373347 |