Detailed description page of Selected OV_ID


OV_4227 details
Primary information
OV_IDOV_4227
Virus Name Sindbis virus
StrainAR339
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1 × 10⁶)
In-vivo virus concentration1 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultComplete reduction in tumor volume after 49 days in mice 3 and increase in PFS above 200 days compared to control 75 days
Mode of deliveryIntratumoral
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectIncreased expression of Bcl-2 and Bcl-xL expression
Clinical trialNA
PMID26298056