Detailed description page of Selected OV_ID


OV_4161 details
Primary information
OV_IDOV_4161
Virus Name Measles virus
StrainMV-s-NAP
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeGenetically engineered for expressing H.pylori neutophil activating protein
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with Alisertib (70nM) before 2 hours of MV infection
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman breast cancer cell line
Cell lineMCF-7
Concentration of cell line5000
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration0.1 MOI
In-vitro result60% cell viability after 48 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectVirus and drug both cause induction of IL-24 expression
Clinical trialIn clinical trials
PMID26272026