Detailed description page of Selected OV_ID


OV_3772 details
Primary information
OV_IDOV_3772
Virus Name Vaccinia virus
Strainvv-smac
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeInsertion of smac and gpt gene in TK
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with gemcitabine (50mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineType culture collection of china
Origin of cell lineHuman pancreatic cancer cell line
Cell lineSW1990
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBalb/c nude mice xenograft for SW1990
In-vivo virus concentration2 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume to below 500mm after 56 days
Mode of deliveryIntratumoral
Pathway inductionVirus induce apoptosis in cancer cell
Immunogenic effectNA
Clinical trialNA
PMID30365143