Detailed description page of Selected OV_ID


OV_311 details
Primary information
OV_IDOV_311
Virus Name Adenovirus
StrainAd.4N1-IL24
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineLeukemia cell line
Cell lineHL-60
Concentration of cell line2
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration100 MOI
In-vitro result58% cancer cell viability at 72 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduces apoptosis by upregulating Bax and activated caspase 3 levels
Immunogenic effectInduces expression of IL-24
Clinical trialNA
PMID26554307