Detailed description page of Selected OV_ID


OV_2853 details
Primary information
OV_IDOV_2853
Virus Name Measles virus
StrainAttenuated strain
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineLaboratory grown own culture
Origin of cell lineHuman lung cancer cell line
Cell lineCaco-2
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismRJ:NMRI nude mice xenograft for A549 cell line (1.5 × 10⁷)
In-vivo virus concentration1 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume after 31 days
Mode of deliveryIntratumoral
Pathway inductionActivation of caspase-3
Immunogenic effectNA
Clinical trialNA
PMID23586034