Detailed description page of Selected OV_ID


OV_2768 details
Primary information
OV_IDOV_2768
Virus Name Adenovirus
StrainZD55-lipocalin2
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B55 gene and insertion of lipocalin2 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineShanghai cell collection
Origin of cell lineHuman colorectal cancer cell line
Cell lineSW620
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismnude mice xenograft for Sw620 (1.5 × 10⁷ cells)
In-vivo virus concentration5 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 500 as comapred to control 1500mm and increase in median survival time
Mode of deliveryIntratumoral
Pathway inductionInducing apoptosis and decreasing microvessel density of tumor
Immunogenic effectNA
Clinical trialNA
PMID23464854