Detailed description page of Selected OV_ID


OV_2591 details
Primary information
OV_IDOV_2591
Virus Name Adenovirus
StrainAd.enAFP-E1A-delta-E1B-IL-24
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1A, E1B and addition of AFP and IL-24
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineATCC
Origin of cell lineHuman liver cancer cell line
Cell linePLC
Concentration of cell line5
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration10 MOI
In-vitro result10% cells are viable after 4 days
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduction of apoptosis in cancer
Immunogenic effectUpregulation of GADD34
Clinical trialNA
PMID22790965