| Primary information |
|---|
| OV_ID | OV_2585 |
| Virus Name | Adenovirus |
| Strain | CNHK600-IL24 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Deletion of E1B gene and addition of IL-24 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing IL-24 gene |
| Source of cell line | Shanghai laboratory animal center, China |
| Origin of cell line | Human breast cancer cell line |
| Cell line | MDA-MB-231 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Nu/Nu female mice orthotopic for MDA-MB-231 cell line (8 × 10ⷠcells) |
| In-vivo virus concentration | 1 × 10⸠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume comes to 1000mm as compared to normal 2000 after 42 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis in cancer |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 22640485 |