Detailed description page of Selected OV_ID


OV_2585 details
Primary information
OV_IDOV_2585
Virus Name Adenovirus
StrainCNHK600-IL24
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B gene and addition of IL-24 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineShanghai laboratory animal center, China
Origin of cell lineHuman breast cancer cell line
Cell lineMDA-MB-231
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNu/Nu female mice orthotopic for MDA-MB-231 cell line (8 × 10⁷ cells)
In-vivo virus concentration1 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultTumor volume comes to 1000mm as compared to normal 2000 after 42 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis in cancer
Immunogenic effectNA
Clinical trialNA
PMID22640485