Detailed description page of Selected OV_ID


OV_2046 details
Primary information
OV_IDOV_2046
Virus Name Reovirus
StrainReovirus T3D
Virus typeRNA
Virus familyReoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus strain in combination with Docetaxel (5 mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineHuman prostate cancer cell line
Cell lineLNCaP
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismMice injected with PC3 cell line
In-vivo virus concentration1 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume after day 15
Mode of deliveryIntratumoral
Pathway inductionVirus cause increase in apoptosis
Immunogenic effectNA
Clinical trialNA
PMID21645351