Detailed description page of Selected OV_ID


OV_2012 details
Primary information
OV_IDOV_2012
Virus Name Reovirus
StrainReovirus T3D
Virus typeRNA
Virus familyReoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman glioma cell line
Cell lineU87
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID/NOD mice xenograft for U87 cell line
In-vivo virus concentration1 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 40mm after 12 days
Mode of deliveryIntrtumoral
Pathway inductionVirus alone and in combination enhance apoptosis
Immunogenic effectNA
Clinical trialNA
PMID21607667