Detailed description page of Selected OV_ID


OV_1405 details
Primary information
OV_IDOV_1405
Virus Name Adenovirus
StrainZD55-hTERT
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B gene and addition of shRNA expressing hTERT
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/ c nude mice injected for Ketr-3 cell line
In-vivo virus concentration7 × 10⁸cells per well
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor size after 7 weeks
Mode of deliverySubcutaneous
Pathway inductionInduction of apoptosis
Immunogenic effectNA
Clinical trialNA
PMID19029834