Detailed description page of Selected OV_ID


OV_1258 details
Primary information
OV_IDOV_1258
Virus Name Vesicular stomatitis virus
Strainwild type
Virus typeRNA
Virus familyRhabdoviridae
Modification in virus genomeYes
Virus aloneNo
Virus in combination iwth drug/radiationVSV in combination with cisplatin (0.1 microgram/ml)
Immune gene induction in virus genomeVirus expressing IL-12 gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC3H/HeJ female mice orthotopic for SSC VII cell line
In-vivo virus concentration5 × 10⁸pfu/kg
In-vivo toxicityNA
In-vivo resultTumor size decreases to 0.5 cm² after 20 days
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID18043494