| Primary information |
|---|
| OV_ID | OV_1258 |
| Virus Name | Vesicular stomatitis virus |
| Strain | wild type |
| Virus type | RNA |
| Virus family | Rhabdoviridae |
| Modification in virus genome | Yes |
| Virus alone | No |
| Virus in combination iwth drug/radiation | VSV in combination with cisplatin (0.1 microgram/ml) |
| Immune gene induction in virus genome | Virus expressing IL-12 gene |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | C3H/HeJ female mice orthotopic for SSC VII cell line |
| In-vivo virus concentration | 5 × 10â¸pfu/kg |
| In-vivo toxicity | NA |
| In-vivo result | Tumor size decreases to 0.5 cm² after 20 days |
| Mode of delivery | Intratumorally |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 18043494 |