Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 4. Click on ID to see further detail.
IDVirus nameVirus strainVirus genome typeVirus familyVirus genome modificationVirus aloneVirus in combination with drug/radiationImmune gene insertion in viral genomeSource of cell lineOrigin of cell lineCell lineConcentration of cell lineIn-vitro toxicityAssayIn-vitro virus concentrationIn-vitro resultModel organismIn-vivo virus concentrationIn-vivo toxicityIn-vivo resultMode of deliveryPathway inducedImmunogenic effectClinical trialPMID
OV_3518AdenovirusAdenovirus ZD55-shMYCNDNAAdenoviridaeVirus expressing MYCN geneYesNoNoLab own synthesizedHuman neuroblastoma cell lineLA1-55n/Dox-R2.0E+5 cells per wellNAMTT assay10 MOI50% cells remain viable after 6 daysNoNoNA No responseNAInduction of apoptosis as measured by TUNEL assayNANA28711493
OV_3519AdenovirusAdenovirus ZD55-shMYCNDNAAdenoviridaeVirus expressing MYCN geneNoVirus in combination with doxorubicinNoLab own synthesizedHuman neuroblastoma cell lineLA1-55n/Dox-R2.0E+5 cells per wellNAMTT assay10 MOI2% cells remain viable after 6 daysNoNoNA No responseNAInduction of apoptosis as measured by TUNEL assayNANA28711493
OV_3520AdenovirusAdenovirus ZD55-shMYCNDNAAdenoviridaeVirus expressing MYCN geneYesNoNoLab own synthesizedHuman neuroblastoma cell lineLA1-55n/Dox-RNANANANANABalb/c nude mice xenograft for LA1-55n/Dox-R cell line (2.0E+6)7.0E+8 pfuNA Tumor volume regressed to 800mm after four week compared to normal 1400 mm.NAInduction of apoptosis as measured by TUNEL assayNANA28711493
OV_3521AdenovirusAdenovirus ZD55-shMYCNDNAAdenoviridaeVirus expressing MYCN geneNoVirus in combination with DoxorubicinNoLab own synthesizedHuman neuroblastoma cell lineLA1-55n/Dox-RNANANANANABalb/c nude mice xenograft for LA1-55n/Dox-R cell line (2.0E+6)7.0E+8 pfuNA Tumor volume regressed to 300mm after four week compared to normal 1400 mm.NAInduction of apoptosis as measured by TUNEL assayNANA28711493