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Details of CPPsite entry with Sequence CKYGRKKRRQRRR
Primary information
PEPTIDE SEQUENCECKYGRKKRRQRRR
CPPsite ID 2580, 2582,
PEPTIDE NAMEfTAT, acFTAT
CHIRALITYL, L
LINEAR/CYCLICLinear, Linear
SOURCEProtein derived, Protein derived
CATEGORYCationic, Cationic
SUB CELLULAR LOCALIZATIONVesicles, Vesicles
N-TERMINAL MODIFICATIONExtra Cys and Lys added for labeling of TMR, Acetamidation
C-TERMINAL MODIFICATIONFree, Free
CHEMICAL MODIFICATIONNA, NA
UPTAKE EFFICIENCYdfTAT accumulates inside endosomes already containing DEAC-K9 and that dfTAT endosomal escape is also accompanied by the leakage of luminal DEAC-K9, NA
PROPOSED UPTAKE MECHANISMMacropinocytosis, Macropinocytosis
INVITRO/INVIVOIn vitro, In vitro
CELL LINEHeLa, Neuro-2a and HDF cells, HeLa, Neuro-2a and HDF cells
In VIVO MODELNA, NA
CARGOFluorophore (TMR), Fluorophore (TMR)
PMID24930129, 24930129
PATENTUnknown, Unknown
Tertiary Structure
(Technique)		2580 (PEPstrMOD), 2582 (PEPstrMOD),