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This page gives details of CPPsite entry with ID 2585
Primary information
CPPsite ID2585
PEPTIDE SEQUENCEAYGRKKRRQRRR
PEPTIDE NAMEDOX-T7-TAT-LIP
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEProtein derived
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytosol and Nucleus
N-TERMINAL MODIFICATIONCysteine addition
C-TERMINAL MODIFICATIONFree
UPTAKE EFFICIENCYEfficiently internalized
PROPOSED UPTAKE MECHANISMMacropinocytosis
INVITRO/INVIVOIn vitro and in vivo
CELL LINEC6 and bEnd.3 cells
In VIVO MODELBALB/c mice
CARGONanoparticle (Liposome), Small molecule drug (Doxorubicin), protein (Transferin)
PMID24893333
PATENTUnknown
LENGTH12
Secondary StructureCCCHHHHHTTCC
SMILESN[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)