Welcome to Entry Card of Peptide


This page gives details of CPPsite entry with ID 2215
Primary information
CPPsite ID2215
PEPTIDE SEQUENCEIPLVVPLRRRRRRRRC
PEPTIDE NAMERIPL
CHIRALITYL
LINEAR/CYCLICLinear
SOURCEChimeric
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONFree
C-TERMINAL MODIFICATIONFree
CHEMICAL MODIFICATIONRIPL peptides is conjugated to maleimide-derivatized liposomal vesicles via the thiol-maleimide reaction
UPTAKE EFFICIENCYIncreased from 20 to 70 fold compared to FITC dextran
PROPOSED UPTAKE MECHANISMEndocytic pathway
INVITRO/INVIVOIn vitro
CELL LINELNCaP, SK-OV-3, and MCF-7 as Hpn-expressing cells, DU-145, PC-3, and HaCaT as Hpn-non-expressing cells
CARGOFluorophore (FITC)
PMID24704199
PATENTUnknown
LENGTH16
Secondary StructureCCCCCCCGGGGGGCCC
SMILESN[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CS)CO
Tertiary Structure
(Technique)		View in Jmol  OR Download Structure
  (PEPstrMOD)