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This page gives details of CPPsite entry with ID 2136
Primary information
CPPsite ID2136
PEPTIDE SEQUENCEHHHHHHHHRRRRRRRRRRRRRRR
PEPTIDE NAMESTR-H8R15
CHIRALITYL
LINEAR/CYCLICLinear
SOURCESynthetic
CATEGORYCationic
SUB CELLULAR LOCALIZATIONCytoplasm
N-TERMINAL MODIFICATIONStearylation
C-TERMINAL MODIFICATIONAmidation
UPTAKE EFFICIENCYSTR-H8R15/GAPDH siRNA formulations revealed decreased mRNA levels by 17% at R/P 10, lower than that of STR-H8R8
PROPOSED UPTAKE MECHANISMEndocytosis
INVITRO/INVIVOIn vitro
CELL LINECHO-K1 cells, HeLa
CARGONucleic acid (GAPDH siRNA)
PMID25193363
PATENTUnknown
LENGTH23
Secondary StructureCCSTTTCTTTHHHHHGGGGTTCC
SMILESN[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H](CC1=CNCN1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N
Tertiary Structure
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