Welcome to AntiBP3

AntiBP3 is an updated version of AntiBP and AntiBP2, developed for predicting, scanning and desiging antibacterial peptides against gram-postive, gram-negative and gram-variable bacteria. Antibacterial peptides (ABPs) are specific cationic AMPs against various bacterial species that disturb the bacterial cell membrane with different mechanisms. The ABPs can also hamper intracellular processes of the bacterial pathogen in different ways, such as modulating the enzymatic activity, protein degradation & synthesis and nucleic acid synthesis, which gives an advantage over traditional antibiotics in developing resistance. Based on gram staining, bacteria are divided into three major classes; Gram-positive, Gram-negative and bacterial species such as Mycobacterium sp., Mycoplasma sp., Actinomyces sp., Bacillus sp., Clostridium sp. etc. shows an erratic response to the stain known as Gram-indeterminate or Gram-variable bacteria. Therefore, we develop an in-silico tool that allows the user to predict, scan motif regions and map the ABPs for these three groups of bacteria.

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Reference: Bajiya N, Choudhury S, Dhall A, Raghava GPS. (2024) AntiBP3: A Method for Predicting Antibacterial Peptides against Gram-Positive/Negative/Variable Bacteria. Antibiotics 13, 168..