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| PolysacDB ID | 1579 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 10 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 13-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1580 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 11 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 13-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1581 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 12 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement |
| Curator ID | AA + AS |
| Date of Curation | 13-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1582 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 13 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement |
| Curator ID | AA + AS |
| Date of Curation | 14-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1583 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 14 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 14-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1584 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 15 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 14-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1585 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 16 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 15-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1586 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 17 |
| Antibody Type Class | IgM |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 16-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1587 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 18 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement |
| Curator ID | AA + AS |
| Date of Curation | 16-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1588 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 19 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 16-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1589 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 20 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 16-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1590 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 21 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 16-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1591 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 22 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 17-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1592 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 23 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 17-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1593 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 24 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 17-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1594 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 25 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 17-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1595 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 26 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 18-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1596 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 28 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 18-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1597 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 29 |
| Antibody Type Class | IgG2a |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 18-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1598 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 30 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab cross-reacted with non-modified acetylaed group B capsular polysaccharide. This Mab also cross-reacted with polysialic acid on CHP-134 neuroblastoma cells |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement |
| Curator ID | AA + AS |
| Date of Curation | 19-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1599 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 48 |
| Antibody Type Class | IgG2b |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 19-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1600 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 2 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit and human complement |
| Curator ID | AA + AS |
| Date of Curation | 20-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1601 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 6 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 20-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1602 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 9 |
| Antibody Type Class | IgG1 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease |
| Curator ID | AA + AS |
| Date of Curation | 20-09-2010 |
| References | 9590252 |
| PolysacDB ID | 1603 |
| Carbohydrate Name | N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Neisseria meningitidis Serogroup B (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | It is a homopolymer of α(2-->8) sialic acid |
| BCSDB Structure | N/A |
| Proposed Function | This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins |
| Antigenic Nature | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugate Method | The oligosaccharide-protein conjugate was prepared by stirring a mixture of terminal aldehyde-containing N-Pr meningococcal B oligosaccharide with tetanus toxoid in 0.75 M potassium phosphate buffer, pH 9.0, with sodium cyanoborohydride (40 mg/ml) for 1 day at 40°C, then 2 days at ambient temperature |
| Antibodies | Mab Seam 1 |
| Antibody Type Class | IgG3 |
| Assay System | ELISA, flow cytometry and indirect immunofluorescence |
| Cross Reactivity | This Mab did not cross-react with non-modified acetylaed group B capsular polysaccharide |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be useful for the identification of molecular mimetics capable of eliciting protective antibodies specific to the bacteria, without the risk of evoking autoimmune disease. This Mab induced bactericidal activity with rabbit complement |
| Curator ID | AA + AS |
| Date of Curation | 20-09-2010 |
| References | 9590252 |
|
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |