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| PolysacDB ID | 1093 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (reference strain M62) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 6D11 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab showed a high degree of reactivity with serotypes 4 and 7 and also detected some isolates belonging to serotypes 1, 2, 3, 6, and 8, as well as some nontypeable isolates |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 28-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1094 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (reference strain M62) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 6B4 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab reacted with only 24.2 and 13.8% of homologous isolates, respectively, but detected 63% of the serotype 7 isolates. A minor reactivity was observed with other serotypes |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 28-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1095 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (reference strain M62) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 5E4 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab reacted with only 24.2 and 13.8% of homologous isolates, respectively, but detected 63% of the total 12 serotype 7 isolates. A minor reactivity was observed with other serotypes |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 28-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1103 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (field isolate F6) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 5C5 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab exhibited 75.8 and 27.3% reactivities with 29 serotype 4 and 12 serotype7 isolates, respectively, and partial binding to serotype 1 and nontypeable isolates |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 30-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1104 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (field isolate F6) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 1E10 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab exhibited 75.8 and 27.3% reactivities with 29 serotype 4 and 12 serotype7 isolates, respectively, and partial binding to serotype 1 and nontypeable isolates |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 30-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1108 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Actinobacillus pleuropneumoniae serotype 4 (field isolate F6) (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | N/A |
| BCSDB Structure | N/A |
| Proposed Function | N/A |
| Antigenic Nature | Formalin-fixed A. pleuropneumoniae serotype 4 cells |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab 5H7 |
| Antibody Type Class | IgM |
| Assay System | Whole cell ELISA and slide agglutination tests |
| Cross Reactivity | This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab exhibited 75.8 and 27.3% reactivities with 29 serotype 4 and 12 serotype7 isolates, respectively, and partial binding to serotype 1 and nontypeable isolates |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7 |
| Curator ID | AA + AS |
| Date of Curation | 31-01-2010 |
| References | PMC170200 |
| PolysacDB ID | 1143 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Bacteroides fragilis NCTC 9343 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | -3)α-D-FucpNAc4N(1-->4)α-D-GalpNAc [branched to β-D-Galf(1-->3)] (1-->3)β-D-Galp [branched via 6th and 4th positions to RPyr(2-(1-.C73 |
| BCSDB Structure | N/A |
| Proposed Function | Capsular polysaccharide of B. fragilis may represent a virulence factor |
| Antigenic Nature | Whole cells of a B. fragilis NCTC 9343 enriched for expression of the EDL |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab QUBf5 |
| Antibody Type Class | IgG2b |
| Assay System | Immunoblotting, immunofluorescence, flow cytometry |
| Cross Reactivity | This Mab did not cross-react with B. vulgatus, B. thetawtaomicron, B. ovatus, B. distasonis, B. gingivalis, E. coli or S. aureus. But it reacted with B. fragilis strain BE3 |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 15-02-2010 |
| References | 1719202 |
| PolysacDB ID | 1144 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Bacteroides fragilis NCTC 9343 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | -3)α-D-FucpNAc4N(1-->4)α-D-GalpNAc [branched to β-D-Galf(1-->3)] (1-->3)β-D-Galp [branched via 6th and 4th positions to RPyr(2-(1-.C73 |
| BCSDB Structure | N/A |
| Proposed Function | Capsular polysaccharide of B. fragilis may represent a virulence factor |
| Antigenic Nature | Whole cells of a B. fragilis NCTC 9343 enriched for expression of the EDL |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab QUBf6 |
| Antibody Type Class | IgG1 |
| Assay System | Immunoblotting, immunofluorescence, flow cytometry |
| Cross Reactivity | This Mab did not cross-react with B. vulgatus, B. thetawtaomicron, B. ovatus, B. distasonis, B. gingivalis, E. coli or S. aureus. But it reacted with B. fragilis strain BE4 |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 15-02-2010 |
| References | 1719202 |
| PolysacDB ID | 1145 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Bacteroides fragilis NCTC 9343 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | -3)α-D-FucpNAc4N(1-->4)α-D-GalpNAc [branched to β-D-Galf(1-->3)] (1-->3)β-D-Galp [branched via 6th and 4th positions to RPyr(2-(1-.C73 |
| BCSDB Structure | N/A |
| Proposed Function | Capsular polysaccharide of B. fragilis may represent a virulence factor |
| Antigenic Nature | Whole cells of a B. fragilis NCTC 9343 enriched for expression of the EDL |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab QUBf7 |
| Antibody Type Class | IgG1 |
| Assay System | Immunoblotting, immunofluorescence, flow cytometry |
| Cross Reactivity | This Mab did not cross-react with B. vulgatus, B. thetawtaomicron, B. ovatus, B. distasonis, B. gingivalis, E. coli or S. aureus. But it reacted with B. fragilis strain BE5 |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 16-02-2010 |
| References | 1719202 |
| PolysacDB ID | 1146 |
| Carbohydrate Name | High molecular weight polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe Name | Bacteroides fragilis NCTC 9343 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | -3)α-D-FucpNAc4N(1-->4)α-D-GalpNAc [branched to β-D-Galf(1-->3)] (1-->3)β-D-Galp [branched via 6th and 4th positions to RPyr(2-(1-.C73 |
| BCSDB Structure | N/A |
| Proposed Function | Capsular polysaccharide of B. fragilis may represent a virulence factor |
| Antigenic Nature | Whole cells of a B. fragilis NCTC 9343 enriched for expression of the EDL |
| Carrier Name | Nil |
| Conjugate Method | Nil |
| Antibodies | Mab QUBf8 |
| Antibody Type Class | IgG1 |
| Assay System | Immunoblotting, immunofluorescence, flow cytometry |
| Cross Reactivity | This Mab did not cross-react with B. vulgatus, B. thetawtaomicron, B. ovatus, B. distasonis, B. gingivalis, E. coli or S. aureus. But it reacted with B. fragilis strain BE6 |
| Proposed Epitope | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 16-02-2010 |
| References | 1719202 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |